Please select a
Sibylla is an early-stage drug discovery company. Sibylla's proprietary technology allows the simulation of the folding pathway from the aminoacid sequence as produced by the cells' ribosomes to the native state. Sibylla can perform the entire folding simulation of biologically relevant proteins, characterizing long-lived and previously unexplored folding intermediate structures at atomic resolution. Small molecules binding to pockets in the intermediate folding states eventually prevent the protein folding and lead the protein to degradation. Such pockets disappear in the native state, which is why Sibylla's technology enables targeting and degrading proteins that have been so far considered undruggable.
Sibylla platform technology is called PPI-FIT (Pharmacological Protein Inactivation by Folding Intermediate Targeting). Our pipeline is currently progressing towards preclinical development.
The degradation activity of the PPI-FIT degraders could resolve severe pathologies, and the impact on society could be disruptive.
Italian leading specialist in custom development and contract manufacturing of Active Pharmaceutical Ingredients, ICROM is the boutique outfit for APIs. Leveraging sophisticated know-how, ICROM builds high-tech solutions to create complex molecules and develop flexible, scalable and cost-effective processes, tailored to customers’ needs. Manufacturing operations are held in 4 state-of-the-art manufacturing units, with multi-scale capacity, where we can manufacture GMP APIs from few hundreds of gram per batch (clinical scale) up to tons (commercial scale). All our units work under cGMP and are approved by EMA, USFDA, Japanese PMDA.
ICROM’s capabilities include a dedicated GMP unit for high-potent API manufacturing.
ICROM is the partner of choice for CDMO of NCEs, high-tech generics, branded generics and your challenge to innovation!
InSilicoTrials.com is a cloud-based platform that provides validated models and simulations to CROs, Pharma and MedTech companies in need of significantly reducing costs and time of drugs and medical device development. This solution is based on three layers that tackle the main hurdles to simulation adoption:
1. A simplified and unified user interface, built on guided workflows, that “translates” data already familiar to scientists into inputs for the models and simulation solvers.
2. Possibility to simulate applications of medical devices and new drugs in virtual environments validated and compliant to the requirements of regulatory subjects for traditional clinical trials.
3. A cloud-based, cybersecure environment that integrates optimized IT resources and a wide range of simulation software.
The latest models available are focused on drug-induced cardiac toxicity screening, and are coming from the FDA and top EU universities.
Olon Group is a global leader in the development and production of active pharmaceutical ingredients (APIs) for CDMO and Generics. It provides an integrated package of chemical synthesis and biological processing services which clients can use to manage their drug manufacturing projects fully compliant with regulations. We rely on a global network of 11 manufacturing site and 7 R&D departments across the globe, on several decades of experience in supporting pharmaceutical, biotech, food, chemical and bio-industrial companies. Thanks to 2.300 employees and 300 highly experienced and qualified people in R&D team, we are a highly reliable partner. In Olon, expertise and competence are combined with great flexibility at different levels, remarkably in the field of microbial fermentation, always considering human safety and environmental security.
ReiThera is a biotech company dedicated to the development, GMP manufacturing and clinical translation of genetic vaccines and medicinal products for advanced therapies. ReiThera will harness its pioneering expertise in the development, GMP manufacture and clinical testing of multiple vector types like AD, AAV, MVA, HSV, LV, alongside with their state-of-the-art facility consisting of more than 2500 m2 dedicated to cGMP Class B and C GMP areas quality control laboratory and inclusive of a filling suite. With a production capacity based on bioreactors at the scale of 2L, 50L, 200L, 1000L, 2000L and on fixed bed bioreactors, ReiThera can offer a manufacturing support from the early phase, including vectors engineering, up to large cGMP scale production for phase I, II, III and commercial supply.
ReiThera offer also immunomonitoring and Immunocharacterization testing of biologic compounds during pre and clinical trial.
Incorporated in 2010, Remembrane is a European SME with the mission to lead the cell culture technology a step forward, by envisaging the cell membrane network and its lipid composition as a cornerstone of cell physiology. Remembrane designs, develops and manufactures customised GMP-grade membrane-targeting Lipid Mixtures commercialized under the brand name Refeed. They are able to boost key performance parameters of any kind of cultured cells, from microorganisms (bacteria, yeast) to human cells (cell lines, primary cells, stem cells). Refeed are used by many international customers of the pharmaceutical and industrial biotechnology sectors, with main applications in the fields of biomanufacturing, in-vitro testing, advanced therapies.
Axxam is an innovative Partner Research Organization (iPRO) and a leading provider of integrated discovery services across life sciences industries, including pharmaceuticals, crop protection, animal health, cosmetics, fragrances, food and beverages. We have consolidated expertise in performing cell-based and biochemical assay development, high-throughput screening of both the Axxam high quality compound collections (small molecule compound libraries and natural product library) or those provided by our clients, compound management, hit identification and hit validation. Our innovative technologies include electrophysiology, high content screening, genome editing, optogenetics and iPSCs, among others.
Axxam’s business terms are flexible, ranging from fee-for-service to FTE-based services.
Our performance-driven approach has been recognized by our clients as key to the success for their early-stage drug discovery programs.
Piemonte Agency guarantees complete assistance to foreign companies willing to invest in Piemonte. Piemonte Agency can advise on every aspect of starting and running a business in Piemonte, providing assistance at every stage of the project. In addition, the Agency acts as a liaison office between foreign investors and public authorities, academic/research networks, industry. All services are free and totally confidential.
BIOREP is a Sapio Group Company established in Milan in 2003. It’s the first Biological Resource Centre able to provide public/private research institutions, biotech and pharmaceutical companies services for the preservation of biological material guaranteeing the highest levels of quality and safety. BIOREP provides cellular, molecular biology, NGS/prenatal screening services, offers integrated solutions for Laboratories with monitoring and control system for the preservation of biological materials.
Eywa srl is a medical device manufacturer that produces and sells innovative products for regenerative medicine. Our core business is an electro-medical device called Limfa Therapy that accelerates the repair of bone and soft tissue damaged by trauma or chronic pathologies (osteoporosis, delayed consolidation, arthrosis, etc.) and is able to stimulate the differentiation of stem cells into type 2 collagen in a stylistically relevant manner.
The extracorporeal stimulation occurs through the use of ultra- and super-weak, complex, variable and bipolar magnetic fields that have been patented by us and that form 29 stimulation sequences with the aim of selectively opening certain ion channels, causing the desired cellular reaction. The technology is fully automatic (programmes are preloaded in the device) and operator independent.
TheProphetAI is a technology startup bringing AI to the life science sector. Our AI-based services address the challenges that different players in this field may face. On one side, we assist suppliers and distributors of biological reagents in better understanding their customers' demands. As well as helping researchers during their work, we also provide a free AI-powered web application called www.GeneRecommender.com. At TheProphetAI we believe that a new era will be brought about by humans' unique skills combined with the capabilities of artificial intelligence. Using user-friendly applications powered by extremely advanced Machine Learning models, TheProphetAI enables its customers to take full advantage of artificial intelligence.
Sensosan is a Benefit Company to resolve a huge problem: improve the wellbeing of people on experience, health safety, mental health.
We do with Intelligent Nebulizers and with Fragrances for scent experience, sanitizing health safety and Functional for mental health.
Our innovative start-up was born in 2020 during the pandemic in Rome and at the Innovation Hub of Rovereto and it is composed of an entrepreneurial and research team with experience.
Our ESG vision is to improve SDGs: 3 Good Health & Wellbeing - 6 Clean Water & Sanification - 8 Decent Work & Economic Growth - 9 Industry, Innovation & Infrastructure - 11 Sustainable Cities & Communities - 15 Life On Land.
Our goal today is to help to return safety on indoor environments.